We fight not only inflammation but also pain, to restore quality of life.
Chronic inflammation is the silent driver behind persistent pain and the degeneration of discs, cartilage and tendons. Oxygen-ozone therapy works at the root of this process, with a high safety profile and without the side effects typical of long-term medication.
Inflammation is, at its origin, a defence mechanism: it isolates damage and initiates repair. The problem arises when it does not switch off. Low-grade chronic inflammation stays active for months or years, keeps tissues in a permanent state of alert and produces two consequences: persistent pain and the progressive degeneration of the joints.
At the molecular level, persistent inflammation is sustained by NF-κB, the main pro-inflammatory transcription factor, which stimulates the production of cytokines (TNF-α, IL-1β, IL-6) and free radicals. This oxidative environment damages cells, sensitises nerve endings and accelerates tissue wear.
Treating pain therefore means acting on this vicious circle — not merely masking the symptom — favouring effective and well-tolerated therapies that do not require long-term use of anti-inflammatory drugs, with their effects on the stomach, kidneys and cardiovascular system.
Book an assessmentMedical ozone activates the antioxidant Nrf2 pathway, which in turn curbs NF-κB, the molecular switch of inflammation.
Documented reduction in pro-inflammatory cytokines and oxidative-stress markers in chronic inflammatory diseases.
In clinical studies on injectable ozone therapy the incidence of side effects is very low and the events described are mild and transient.
How chronic inflammation turns a passing discomfort into a degenerative condition.
Degenerative musculoskeletal processes — osteoarthritis, disc degeneration, chronic tendinopathies — are not simply the result of age or mechanical wear. They are biologically active processes, in which inflammation plays a central role in maintaining and accelerating the damage.
The intervertebral disc is a poorly vascularised structure, nourished by diffusion. When it cracks or bulges, material from the nucleus pulposus comes into contact with the immune system and triggers an intense inflammatory reaction. It is the inflammatory cytokines, even more than simple mechanical compression, that irritate the nerve root and generate the pain of sciatica and low back pain. Reducing local inflammation therefore means addressing the real cause of the pain.
In osteoarthritis of the knee, hip or shoulder, the cartilage thins progressively. The process is fuelled by enzymes (metalloproteinases) activated precisely by inflammatory cytokines: more inflammation means more degradation of the cartilage matrix, which in turn releases fragments that feed further inflammation — a self-sustaining cycle.
In tendinopathies (shoulder, elbow, Achilles tendon) the tendon tissue loses its ordered structure and is replaced by disorganised, weaker tissue. Here too, the oxidative, inflammatory environment hinders the tendon's natural repair.
The common denominator is the redox imbalance: an excess of free radicals compared with the cell's antioxidant defences. This imbalance is now recognised as one of the fundamental mechanisms of tissue ageing. Acting on it means not only reducing pain, but supporting the repair capacity of tissues over time.
A targeted response to inflammation and oxidative stress, with high tolerability.
Oxygen-ozone therapy uses a mixture of oxygen (O₂) and ozone (O₃) in controlled concentrations for therapeutic purposes. Medical ozone cannot be bottled: it is produced on the spot with dedicated equipment and dosed precisely by the physician for each condition and treatment area.
The mechanism is based on an apparently paradoxical principle, oxidative preconditioning: controlled amounts of ozone generate a mild, transient oxidative stimulus that "trains" the cell to activate its own defence systems. The Nrf2 pathway is activated, endogenous antioxidant enzymes increase (superoxide dismutase, catalase, glutathione peroxidase) and NF-κB is simultaneously curbed, with a consequent reduction of inflammatory cytokines.
In addition, it improves tissue oxygenation — particularly important in poorly vascularised structures such as the intervertebral disc and tendons, where low oxygen helps sustain the degenerative process.
Modulates the mediators of inflammation, activates the Nrf2 pathway and reduces the expression of the pro-inflammatory cytokines responsible for persistent pain.
Reduces the sensitisation of nerve endings and pain, with particularly strong evidence for low back pain caused by a herniated disc.
Strengthens endogenous antioxidant defences, supporting the redox balance underlying the processes of tissue ageing and degeneration.
Beyond local injections, ozone can act on the whole body through the blood, with a systemic antioxidant and immunomodulating effect.
A volume of venous blood (usually 100–200 ml) is drawn in a closed, sterile circuit, mixed with a precise amount of oxygen-ozone at a controlled concentration (typically 10–40 µg/mL) and reinfused. The usual cycle is 5–10 weekly sessions, repeatable 1–2 times a year. It stimulates antioxidant defences (Nrf2 pathway), modulates the immune response and improves tissue oxygenation and microcirculation.
A small amount of blood (a few millilitres) is mixed with ozone and re-injected intramuscularly. It works mainly as an immunomodulating stimulus — a kind of biological "auto-vaccine" — useful in some allergic and immune conditions. It is a quick, outpatient procedure.
Reference literature. Reviews and evidence classifications on systemic ozone and autohemotherapy: Medical ozone: mechanisms, biological effects and clinical evidence — Frontiers in Medicine (2026) · Ozone therapy in musculoskeletal medicine — Eur J Med Res (2024) · Major ozone autohemotherapy in post-COVID syndrome — Frontiers (2026) · ISCO3 — Major Autohemotherapy Methodology. These indications are potential applications, assessed by the physician on a case-by-case basis.
Intravenous administration of molecules with antioxidant and metabolic effects, in personalised protocols defined by the physician after a clinical assessment. Below are the main ones, with their function and a literature reference.
The main antioxidant produced by the body ("master antioxidant"): it neutralises free radicals, supports liver detoxification and protects cells from oxidative stress. It has also been studied intravenously, though the clinical evidence is still preliminary.
IV trial · Movement Disorders (2009) ↗Replenishes glutathione stores, with antioxidant, mucolytic and anti-inflammatory action. Well established in intravenous clinical use (e.g. paracetamol poisoning, prevention of contrast-induced nephropathy).
Meta-analysis of IV infusion RCTs ↗A coenzyme central to cellular energy production and DNA repair; its levels tend to decline with age. Used in longevity protocols, where the clinical evidence is promising but still evolving.
IV infusion study (2019) ↗Intravenously it reaches concentrations not achievable orally. It supports the immune system and collagen synthesis; studied as adjuvant support in oncology and for quality of life. The evidence applies to specific areas and is not conclusive.
IV trial · JAMA (2019) ↗An antioxidant active in both aqueous and lipid environments, able to regenerate other antioxidants. Useful in neuropathic pain and metabolic support, with a good safety profile.
IV trial · Diabetologia (ALADIN) ↗Coenzymes of energy metabolism and neurological function. Vitamin B12 is essential for red blood cell production and nervous system function; deficiency can cause haematological and neurological disorders.
Clinical review (parenteral use) ↗Involved in hundreds of enzymatic reactions; it supports muscle and nerve function and energy metabolism. It is a classic component of multivitamin infusions (the so-called "Myers' cocktail").
IV trial · Lancet Respir Med (2013) ↗⚕️ Important note. The intravenous therapies described here have variable levels of evidence and are offered as support, within a personalised medical assessment: they do not replace treatments with an established indication. Every protocol, dosage and indication is set by the physician after a visit, taking into account medical history, tests and ongoing therapies.
Inflammatory and degenerative conditions that can benefit from pain management and oxygen-ozone therapy.
A clear, personalised pathway, monitored over time.
Complete clinical evaluation, analysis of the pain history and review of imaging and tests already carried out.
Definition of the most suitable treatment, the number of planned sessions and the realistic goals to be reached.
Short outpatient sessions, generally well tolerated, with an immediate return to normal activities.
Reassessment of results, guidance for maintenance and prevention of recurrences.
Peer-reviewed references on the anti-inflammatory, antinociceptive and antioxidant effects of medical ozone.
⚕️ Information note. The content on this page is for information only and does not replace a medical examination or specialist consultation. The indication for any treatment must always be assessed by the physician on a case-by-case basis. Results may vary from patient to patient.
An anaesthesiologist and intensivist, I focus on pain management and oxygen-ozone therapy. My approach stems from the belief that caring means looking after the person as a whole, not just treating an isolated symptom.
I obtained my specialisation in Anaesthesia, Intensive Care and Pain Medicine in Florence. My experience in anaesthesia and intensive care has taught me to see pain as a complex phenomenon with a precise biological basis. That is why, faced with persistent pain, the first goal is to understand which process — almost always inflammatory — is feeding it, and to act on that.
For each patient I build a tailored pathway that starts from an accurate clinical assessment and favours conservative, minimally invasive treatments, with the aim of reducing pain and restoring quality to everyday life.
I am a member of SIOOT — the Italian Scientific Society of Oxygen-Ozone Therapy and I follow its standardised clinical protocols.
The experiences of those who have entrusted themselves to my care. Have you had an appointment or treatment? Your feedback helps other patients choose with confidence.
⭐ Read and leave a reviewYou can choose a date and time through MioDottore, or contact me by phone for any information.
📅 Book on MioDottore You will be redirected to the official booking page.Pain management and oxygen-ozone therapy clinic in Segrate, at the gateway to Milan.
